Website last updated 29/06/2025
Hypertension
Key Considerations
- Up to 50% of patients do not adhere to BP treatment over time
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- Weight and blood pressure are closely related. Losing weight generally reduces blood pressure
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- It can take a few weeks before the full effect of the blood pressure medication to take place
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- Kidney function (eGFR) tends to decline with age
Other considerations
- Patients should be encouraged to have a home blood pressure monitor. Some surgeries allow patient's to loan BP monitors.
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- Blood tests requirements depend on the medication being prescribed
Treatment choice

Blood pressure targets
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Reviewing the patient/ Titration
- Check blood pressure around 3- 4 weeks after starting a new treatment or changes to a dose of an existing antihypertension
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- If the patient's blood pressure is especially high (stage 2 or 3), you can check their BP readings sooner
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- Clinic blood pressure can be used at first. If the patient's blood pressure is still above the target, then advise the patient to complete 4-7 days of HBPM.
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- If the average HBPM reading is still above the target, then consider intensifying treatment (increasing the dose of current antihypertensives, or introducing a further agent)
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HBPM counselling
- Avoid eating, exercising, or taking medication before the reading
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- Avoid caffeine intake at least 2 hours before the reading
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- Ensure cuff is at heart level
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- Sit quietly 5 minutes before taking readings
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- Try not to move or talk whilst taking readings
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- Measure BP around the same time each day
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- Take 3 measurements 1-2 minutes apart
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- 3 morning readings and 3 evening readings for 4-7 days
Monitoring

- It’s good practice to perform annual cardiovascular blood tests—such as HbA1c and non-fasting lipids—for patients on antihypertensives
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- Baseline U&Es should be checked before starting ACEi/ARBs, spironolactone, or thiazide-like diuretics to monitor for any impact on kidney function
Hypertension in Diabetes/ CKD
- ACEi or ARB drugs are first line for hypertension in diabetes as they have a kidney protection effect
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- 140/90mmHg target clinic blood pressure
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- 130/80mmHg target for people with :
- CKD and diabetes
- an ACR of 70 mg/mmol or more
Sick day guidance
- Stay hydrated and try to maintain usual calorie intake
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- Which medications to pause:
- ACEi/ARBs - risk of kidney damage
- Diuretics - risk of dehydration
- NSAIDs - risk of kidney damage
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- Medications can be restarted 24-48 hours after patient is feeling well
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Safety netting/Counselling
- Advise patient to call book an appointment or call 111 if they become hypotensive (BP reading of 90/60)
- If patient is also experiencing moderate/severe symptoms of hypotension they can be advised to visit A&E
- Consider titrating treatment down and performing 4-7 days of HBPM
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- Advise on symptoms of heart attack and stroke and to call 999
FAQ's
What should I be looking out for when checking U&Es
If a decline in eGFR or changes in electrolytes is seen, ensure patient was well hydrated prior to the reading and consider repeating U&Es
What time of the day should patient's take their medication?
It is up to patient preference, however patients should try to take their medication around the same time each day
References
https://www.nice.org.uk/guidance/ng136
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https://cks.nice.org.uk/topics/hypertension/
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https://www.sps.nhs.uk/monitorings/spironolactone-monitoring/
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https://www.sps.nhs.uk/monitorings/ace-inhibitors-and-angiotensin-ii-receptor-blockers-monitoring/​
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https://bnf.nice.org.uk/treatment-summaries/beta-adrenoceptor-blocking-drugs/
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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.313220